Archives: Month: April 2025
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April 15, 2025
Personalized Care for DCIS: New Genetic Score Offers Hope
While most cases of DCIS stay harmless, some can eventually turn into invasive cancer, which is harder to treat. Right now, it’s difficult for doctors to predict which DCIS cases are likely to progress, often leading to overtreatment with surgery or radiation for many women. A new study published in Cell Death Discovery aimed to find a better way to predict which DCIS cases might turn aggressive and threaten a patient’s health. In the study, researchers looked very closely at thousands of individual breast cancer cells from patients at different stages of disease. They identified nine important genes that behave differently in invasive versus non-invasive cells. Using these…
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April 12, 2025
New Gene Test Helps Personalize Radiation and Hormone Treatment Decisions for DCIS Patients
Traditionally, doctors use physical and medical factors to decide if DCIS patients need radiation or hormone therapy following surgery. But this method is not always accurate. A study presented at the 42nd Annual Miami Breast Cancer Conference showed a 7-gene biosignature test could more accurately identify DCIS patients who would actually benefit from radiation and/or hormone therapy after breast-conserving surgery, compared to traditional clinicopathologic risk criteria. Researchers analyzed tissue samples from 926 DCIS patients. They found that women labeled “low risk” by traditional methods included a substantial number of women who, per the 7-gene test, were actually at higher risk and did benefit from radiation. Other women who were correctly…