Archives: Month: February 2026

Is Tamoxifen Alone Without Surgery a Viable Strategy for Low-Risk DCIS?: Updates From the LORETTA Trial

In December 2025, results from the LORETTA trial were presented at the San Antonio Breast Cancer Symposium (SABCS), offering new insight into an important and long-standing question in DCIS care: Can some people with low-risk DCIS safely avoid surgery?

While the trial did not meet its predefined statistical threshold, the findings add meaningful evidence to the growing body of research suggesting that active surveillance may be appropriate for carefully selected patients. Importantly, the results help clarify who those patients might be.

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